林坤陽助理教授

Current Position

• 2025- Assistant Professor, Institute of Anatomy and Cell Biology, National Yang Ming Chiao Tung University

Education

• 2014-2020 Ph.D.

  Taiwan International Graduate Program (TIGP)

  Academia Sinica/National Chung-Hsing University

• 2007-2009 M.Sc.

  Institute of Biochemistry and Molecular Biology

  National Yang Ming University, Taiwan

Appointments

• 2020-2024, Postdoctoral Research Fellow,

  Duke-NUS Medical

  School, National University of Singapore (NUS), Singapore

Honors and Awards

• 2024, Outstanding Research Award, The 25th Annual Scientific Meeting of SGH, Singapore
• 2023, Open Fund Young Individual Research Grant Award, NMRC, Singapore
• 2022, Khoo Postdoctoral Fellowship Award, Duke-NUS Medical School, Singapore
• 2021, The 17th Tien Te Lee (李天德) Biomedical Awards - Distinguished Thesis Prize, Taiwan
  
• 2020, Postdoctoral Research Abroad Program Award, MOST, Taiwan
• 2020, Presidential Fellowship Award, TIGP, Academia Sinica
• 2020, Dr. Chien-Tien Hsu Award - Outstanding Thesis Award, Taiwan
  

Research expertise

• Stem Cell Biology, Neurobiology, Development Biology

Publications

1. Gao Y, Tan YS, Lin J, Chew LC, Aung HY, Palliyana B, Gujar M, Lin KY, Kondo S, Wang H. SUMOylation of Warts Kinase Promotes Neural Stem Cell Reactivation. Nature Communications (2024) (Journal Impact Factor, JIF: 14.7)
   
2. Ma DL, Lin KY, Divya S, Lin J, Gujar M, Aung HY, Tan YS, Chen T, Wang H. Arl2 Associates with Cdk5rap2 to Regulate Cortical Development via Microtubule Organization. PLoS Biology (2024) (JIF: 7.8)
3. Lin KY, Gujar M, Lin J, Ding WY, Huang J, Gao Y, Tan YS, Teng X, Toyama Y, Wang H. Astrocytes Control Quiescent NSC Reactivation via GPCR Signaling-mediated F-actin Remodeling. Science Advances (2024) (JIF: 11.7)
4. Gujar M, Gao Y, Teng X, Deng Q, Lin KY, Tan YS, Toyama Y, Wang H. Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells. Developmental Cell (2023) (JIF: 10.7)
5. Chen TA¶, Lin KY¶, Yang SM¶, Tseng CY, Wang YT, Lin CH, Luo L, Cai Y, Hsu HJ. Canonical Wnt Signaling Promotes Formation of Somatic Permeability Barrier for Proper Germ Cell Differentiation. Frontiers in Cell and Developmental Biology (2022) ¶Co-first author. (JIF: 4.6)
6. Lin KY, Wang WD, Lin CH, Rastegari E, Su YH, Chang YC, Chang YT, Liao YF, Pi H, Yu BY, Chen SH, Lin CY, Lu MY, Tzou FY, Chan CC, Hsu HJ. Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. Nature Communications (2020) (JIF: 14.7) Selected as TOP 20 research articles of Life Science in Research Highlights of Academia Sinica 2020
7. Lin KY and Hsu HJ. Regulation of adult female germline stem cells by nutrient-responsive signaling. Current Opinion in Insect Science (2020) (JIF: 5.8)
8. Amartuvshin O, Lin CH, Hsu SC, Chen A, Kao SH, Tang WC, Chou HL, Hsiao BS, Lin KY, Wang YT, Yao CK, Chen GC, Chen BC, Hsu HJ. Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss. Aging Cell (2020) (JIF: 8.0)
9. Lin SC¶, Lin CH¶, Shih NC, Liu HL, Wang WC, Lin KY, Lin YC, Yeh YC, Minato H, Fujii T, Wu YC, Chen MY, Chou TY. Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling. Oncogene (2019) (JIF: 6.9)
10. Tseng CY, Su YH, Yang SM, Lin KY, Lai CM, Cho Y, Cai Y, Hsu HJ. Smad-independent BMP signaling in somatic cells limits the size of the germline stem cell pool during ovary development. Stem Cell Reports (2018) (JIF: 5.9)
11. Cho Y¶, Lai CM¶, Lin KY, Hsu HJ. A targeted RNAi screen reveals Drosophila female-sterile genes that control the size of germline stem cell niche during development. G3: GENES, GENOMES, GENETICS (2018) (JIF: 2.1)
12. Su YH, Rastegari E., Kao SH, Lai CM, Lin KY, Liao HY, Wang MH, and Hsu HJ. Diet regulates membrane extension and survival of niche escort cell for germline homeostasis via insulin signaling. Development (2018) (JIF: 3.7)
13. Lai CM, Lin KY, Kao SH, Chen YN, Huang F, Hsu HJ. Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion. Journal of Cell Biology (2017) (JIF: 7.4)
14. Lin KY, Kao SH, Lai CM, Chen CT, Wu CY, Hsu HJ, Wang WD. Tumor suppressor Lzap suppresses Wnt/β-catenin signaling to promote zebrafish embryonic ventral cell fates via the suppression of inhibitory phosphorylation of GSK3. Journal of Biological Chemistry (2015) (JIF: 4.0)
15. [Chiu CH, Ho HL, Chiang CL, Lin SF, Ma HH, Chuang YT, Lin KY, Tsai CM, Chou TY. Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays. Journal of Thoracic Oncology (2014) (JIF: 21.0)
16. Ho HL, Chang FP, Ma HH, Liao LR, Chuang YT, Chang-Chien YC, Lin KY, Chou TY. Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods. Respirology (2013) (JIF: 6.6)