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師資簡介Faculty

林坤陽照片
林坤陽助理教授

Kun-Yang Lin, Ph.D. Assistant Professor

辦公室 A110 #67967

實驗室 A121 #65437、65438

kunyang.lin@nycu.edu.tw

https://kunyanglin.mystrikingly.com

實驗室介紹

我們是一個研究神經新生(Neurogenesis)的實驗室，致力於探索腦部發育與相關神經發育障礙疾病的奧秘，利用果蠅大腦和人類類腦組織培養為模型模式來探討神經幹細胞如何被調控以幫助神經新生及大腦的發育，並為神經發育障礙疾病發展可能的治療標的。


實驗室研究方向

我們的實驗室致力於探索腦部發育與相關疾病的機制，特別是研究神經幹細胞如何從休眠狀態被喚醒，並啟動新神經元的生成。我們結合果蠅與人類類腦器官這兩種強大的研究模型，利用遺傳學、生物化學、分子生物學及生物影像分析技術，深入了解神經幹細胞的活化機制與其在腦部發育中的關鍵角色。此外，我們也專注於神經發育障礙的致病機制，針對自閉症和小頭症等神經發育障礙的致病基因，期望揭示背後的機制，為未來的治療策略提供新的希望與方向。


實驗室目前的研究方向:

1.探討神經幹細胞的顯微環境(niche)如何影響幹細胞的行為。

2.探討星狀膠質細胞如何喚醒休眠中的神經幹細胞。

3.探討自閉症類群障礙（Autism Spectrum Disorder）的致病基因如何影響神經幹細胞的行為。

教師資訊

林坤陽助理教授

現職

  • 2025- 助理教授，解剖學及細胞生物學研究所，國立陽明交通大學
  • 個人的網頁連結

學歷

  • 2014-2020 博士，國際研究生學程，中央研究院/國立中興大學
  • 2007-2009 碩士，生物化學暨分子生物學研究所，國立陽明大學

經歷

  • 2020-2024 博士後研究員, 杜克-國立新加坡大學醫學院, 新加坡

重要獎項與榮譽

  • 2024，傑出研究獎，第25屆新加坡綜合醫院年度科學會議，新加坡
  • 2023，年輕研究學者開放基金獎，國家醫學研究委員會，新加坡
  • 2022，Khoo博士後獎學金, 杜克-國立新加坡大學醫學院，新加坡
  • 2021，第17屆永信李天德醫藥科技獎傑出論文獎，臺灣
  • 2020，博士後海外研究計畫獎(千里馬計畫)，國家科學及技術委員會，臺灣
  • 2020，國際研究生學程院長獎學金獎，中央研究院
  • 2020，徐千田博士獎傑出論文獎，臺灣

研究專長

  • 幹細胞生物學，神經生物學，發育生物學

發表論文

  1. Gao Y, Tan YS, Lin J, Chew LC, Aung HY, Palliyana B, Gujar M, Lin KY, Kondo S, Wang H. SUMOylation of Warts Kinase Promotes Neural Stem Cell Reactivation. Nature Communications (2024) (Journal Impact Factor, JIF: 14.7)
  2. Ma DL, Lin KY, Divya S, Lin J, Gujar M, Aung HY, Tan YS, Chen T, Wang H. Arl2 Associates with Cdk5rap2 to Regulate Cortical Development via Microtubule Organization. PLoS Biology (2024) (JIF: 7.8)
  3. Lin KY, Gujar M, Lin J, Ding WY, Huang J, Gao Y, Tan YS, Teng X, Toyama Y, Wang H. Astrocytes Control Quiescent NSC Reactivation via GPCR Signaling-mediated F-actin Remodeling. Science Advances (2024) (JIF: 11.7)
  4. Gujar M, Gao Y, Teng X, Deng Q, Lin KY, Tan YS, Toyama Y, Wang H. Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells. Developmental Cell (2023) (JIF: 10.7)
  5. Chen TA¶, Lin KY¶, Yang SM¶, Tseng CY, Wang YT, Lin CH, Luo L, Cai Y, Hsu HJ. Canonical Wnt Signaling Promotes Formation of Somatic Permeability Barrier for Proper Germ Cell Differentiation. Frontiers in Cell and Developmental Biology (2022) ¶Co-first author. (JIF: 4.6)
  6. Lin KY, Wang WD, Lin CH, Rastegari E, Su YH, Chang YC, Chang YT, Liao YF, Pi H, Yu BY, Chen SH, Lin CY, Lu MY, Tzou FY, Chan CC, Hsu HJ. Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling. Nature Communications (2020) (JIF: 14.7) Selected as TOP 20 research articles of Life Science in Research Highlights of Academia Sinica 2020
  7. Lin KY and Hsu HJ. Regulation of adult female germline stem cells by nutrient-responsive signaling. Current Opinion in Insect Science (2020) (JIF: 5.8)
  8. Amartuvshin O, Lin CH, Hsu SC, Chen A, Kao SH, Tang WC, Chou HL, Hsiao BS, Lin KY, Wang YT, Yao CK, Chen GC, Chen BC, Hsu HJ. Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss. Aging Cell (2020) (JIF: 8.0)
  9. Lin SC¶, Lin CH¶, Shih NC, Liu HL, Wang WC, Lin KY, Lin YC, Yeh YC, Minato H, Fujii T, Wu YC, Chen MY, Chou TY. Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling. Oncogene (2019) (JIF: 6.9)
  10. Tseng CY, Su YH, Yang SM, Lin KY, Lai CM, Cho Y, Cai Y, Hsu HJ. Smad-independent BMP signaling in somatic cells limits the size of the germline stem cell pool during ovary development. Stem Cell Reports (2018) (JIF: 5.9)
  11. Cho Y¶, Lai CM¶, Lin KY, Hsu HJ. A targeted RNAi screen reveals Drosophila female-sterile genes that control the size of germline stem cell niche during development. G3: GENES, GENOMES, GENETICS (2018) (JIF: 2.1)
  12. Su YH, Rastegari E., Kao SH, Lai CM, Lin KY, Liao HY, Wang MH, and Hsu HJ. Diet regulates membrane extension and survival of niche escort cell for germline homeostasis via insulin signaling. Development (2018) (JIF: 3.7)
  13. Lai CM, Lin KY, Kao SH, Chen YN, Huang F, Hsu HJ. Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion. Journal of Cell Biology (2017) (JIF: 7.4)
  14. Lin KY, Kao SH, Lai CM, Chen CT, Wu CY, Hsu HJ, Wang WD. Tumor suppressor Lzap suppresses Wnt/β-catenin signaling to promote zebrafish embryonic ventral cell fates via the suppression of inhibitory phosphorylation of GSK3. Journal of Biological Chemistry (2015) (JIF: 4.0)
  15. Chiu CH, Ho HL, Chiang CL, Lin SF, Ma HH, Chuang YT, Lin KY, Tsai CM, Chou TY. Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays. Journal of Thoracic Oncology (2014) (JIF: 21.0)
  16. Ho HL, Chang FP, Ma HH, Liao LR, Chuang YT, Chang-Chien YC, Lin KY, Chou TY. Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods. Respirology (2013) (JIF: 6.6)
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