Pei-Shan HOU
Ph.D. Assistant Professor
Research
Welcome to Hou’s laboratory! Our goal is to explore the mystery that establish the highly sophisticated human neocortex. In this end, we could provide a fundamental step towards both understanding and the further developing the medication of human nervous system disorders.
Research Area
Three centuries ago (1664) Thomas Willis proposed that the brain is responsible for the higher cognition, which is known to be mastered by the neocortex of forebrain at present. To delicately process a huge amount of information all the time, the neocortex is divided into multiple functional areas, also called Brodmann’s area (1909). Each area exerts the unique functions, such as primary somatosensory area for receiving information and the neighboring primary motor area for order delivering. The cross-talk of cortical neurons in these areas thus helps us to process the information and deliver the orders for voluntary movements. These in turn lighten on the disorder of human nervous system may not cause death directly but lead to low quality of living. However, the limited understanding of human neocortex has hampered the development of effective medications.
To explore the mystery of human neocortical development to broaden our understanding and developing the medication for neurological disorders, we have two approaches:
- With the evolutional aspect to uncover the mechanism underlying human cortical development
-
Adopt 3D organoid culture system from pluripotent stem cells to mimic nervous system disorder
Faculty Profiles
侯珮珊助理教授
Education
- Doctor of Philosophy: Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University
Appointments
- JSPS Postdoctoral Fellowship 2017~2019
- Postdoctoral Researcher in CDB, RIKEN, Japan 2016~2017
- Visiting Postdoctoral Researcher in CDB, RIKEN, Japan (Supported by MOST, Taiwan)
- Postdoctoral Researcher in Academia Sinica, Taiwan 2013~2015
Honors and Awards
- 2017 JSPS Postdoctoral Fellowship
- 2015 MOST Postdoctoral Research Abroad Program
Research expertise
- Neocortical Development, Neural differentiation of embryonic stem cells
Publications
- Pei-Shan Hou, Darren O hAilin, Tanja Vogel and Carina Hanashima. Transcription and Beyond: Delineating FOXG1 Function in Cortical Development and Disorders. Frontiers in Cellular Neuroscience 2020; 2020 Feb 25;14:35.(2020 Feb 25;14:35.):2020 Feb 25;14:35. (SCI).
- Pei-Shan Hou, Goichi Miyoshi and Carina Hanashima*. Sensory cortex wiring requires preselection of short- and long-range projection neurons through an Egr-Foxg1-COUP-TFI network. Nature Communications 2019; 2019 Aug 8;10(1):3581.(2019 Aug 8;10(1):3581.):2019 Aug 8;10(1):3581. (SCI).
- Pei-Shan Hou, Takuma Kumamoto, Carina Hanashima. A Sensitive and Versatile In Situ Hybridization Protocol for Gene Expression Analysis in Developing Amniote Brains. Methods in Molecular Biology 2017; 1650:319-334(1650:319-334):1650:319-334 (OI).
- Pei-Shan Hou, Ching-Yu Chuang, Chan-Hsien Yeh, Wei Chiang, Hsiao-Jung Liu, Teng-Nan Lin, Hung-Chih Kuo. Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors. Stem Cell Reports 2017; 10;8(1):54-68(10;8(1):54-68):10;8(1):54-68 (SCI).
- Hou PS, Huang WC, Chiang W, Lin WC, Chien CL. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced pluripotent stem cells. Cellular Reprogramming 2014; December 2014, 16(6): 467-476.(December 2014, 16(6): 467-476.):December 2014, 16(6): 467-476. (SCI).
- I-Ying Lin, Feng-Lan Chiu, Chen-Hsiang Yeang, Hsin-Fu Chen, Ching-Yu Chuang, Shii-Yi Yang, Pei-Shan Hou, Nardnisa Sintupisut, Hong-Nerng Ho, Hung-Chih Kuoemail, Kuo-I Lin. Suppression of the SOX2 Neural Effector Gene by PRDM1 Promotes Human Germ Cell Fate in Embryonic Stem Cells. Stem Cell Reports 2014; : (SCI).
- Ashwin S. Shetty, Geeta Godbole, Upasana Maheshwari, Hari Padmanabhan, Rahu Chaudhary, Bhavana Muralidharan, Pei-Shan Hou, Edwin S. Monuki, Hung-Chih Kuo, V. Rema, and Shubha Tole. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A 2013; 110(50):E4913-21(110(50):E4913-21):110(50):E4913-21 (SCI).
- Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL*, Kuo HC*.. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res 2013; Epub ahead of print(Epub ahead of print):Epub ahead of print (SCI).
- Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC.. Kruppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells. Stem Cells. 2010; : (SCI).
- Chen YT, Furushima K, Hou PS, Ku AT, Deng JM, Jang CW, Fang H, Adams HP, Kuo ML, Ho HN, Chien CL, Behringer RR. PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev. 2010; : (SCI).
