Wei-Cheng Jiang
Ph.D. Assistant Professor
Research
Welcome to the Jiang lab! The goal of our lab is to develop innovative strategies for the prevention and treatment of vascular diseases. Our studies take a multidisciplinary approach, by integrating stem cells, biomaterials, vascular biology, 3D printing technology, and tissue engineering.
Research Area
Despite medical advances, there is a continuing threat of vascular diseases. Five of the Taiwan's top ten leading causes of death, such as heart disease, cerebrovascular disease, diabetes, hypertension, and nephropathy, are blood vessel-related diseases. On top of that, population aging further exacerbates the situation. These have tremendous impacts on the health and welfare of people in Taiwan's society. Therefore, the development of strategies for prevention or treatment of vascular diseases is in urgent need. To this end, the emerging regenerative medicine technology might be a promising preventive and/or therapeutic strategy. Based on interdisciplinary technologies, including the research of stem cells and their derivatives, vascular biology, biomaterials, tissue engineering, 3D printing technology, etc., our lab aims to develop innovative strategies for the prevention and treatment of vascular diseases. Our studies focus on the following:
1. To develop pluripotent stem cells differentiation into vascular endothelial and smooth muscle cells as a therapeutic cell source for the treatment of vascular disease;
2. To utilize stem cells combined with biomaterials and 3D printing technology to fabricate novel vascular constructs for the regeneration and repair of ischemic vascular diseases;
3. To adopt induced pluripotent stem cells for establishing in vitro vascular disease models to identify key pathogenic factors or to screen for drug candidates;
4. To establish induced pluripotent stem cells from patients with genetic vascular diseases and to differentiate them into vascular cells for investigating the pathogenic mechanisms or novel therapeutic strategies;
5. To use stem cells or their specific cell derivatives to develop emerging diagnostic or therapeutic strategies for vascular diseases.
Faculty Profiles
蔣偉程助理教授
Current Position
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Assistant Professor, Department of Anatomy and Cell Biology, School of Medicine, National Yang Ming Chiao Tung University
Education
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Ph.D., Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
Appointments
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Postdoctoral Fellow, Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, Taiwan
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Ph.D. On-the-job Training Program (生技高階人才培訓與就業計畫), National Health Research Institutes, Zhunan, Taiwan
Honors and Awards
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Postdoctoral Researcher Academic Research Award, Ministry of Science and Technology (MOST),Taiwan, 2021 (科技部博士後研究人員學術研究獎)
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Excellent Poster Award, 2021 National Health Research Institutes Research Day, Zhunan, Taiwan
- 國家衛生研究院細胞及系統醫學研究所「2020 IDEA」科普競賽活動團體優選獎
- 國家衛生研究院細胞及系統醫學研究所「2020 IDEA」科普競賽活動個人入圍獎
- 國家衛生研究院108年度9月份媒體發布績優案件之肯定獎
- Excellent Poster Award, 2019 National Health Research Institutes Research Day, Zhunan, Taiwan
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2nd Prize in Poster Presentation Award, 2019 International Conference on Biology and Medical Sciences, Okinawa, Japan
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Excellent Paper (Oral Presentation) Award, 2018 National Health Research Institutes Research Day, Zhunan, Taiwan
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Travel Award to ISSCR, 2013 International Symposium on Development, Morphogenesis, and Stem Cells, The 9th Annual Meeting of Taiwan Society for Stem Cell Research, Taipei, Taiwan
Research expertise
- Stem Cell Research
- Tissue Engineering and Regenerative Medicine
- Vascular Biology
Publications
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Chen CH, Ho HH, Jiang WC, Ao-Ieong WS, Wang J, Orekhov AN, Sobenin IA, Layne MD, Yet SF. Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice. J Biomed Sci. 2022;12;29(1):25. (IF=12.771; R/C=11/139, MEDICINE, RESEARCH & EXPERIMENTAL)
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Jiang WC, Hsu WY, Ao-Ieong WS, Wang CY, Wang J, Yet SF. A novel engineered vascular construct of stem cell-laden 3D-printed PGSA scaffold enhances tissue revascularization. Biofabrication. 2021;13(4):045004. (IF=11.061; R/C=9/98, ENGINEERING, BIOMEDICAL)
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Ao-Ieong WS, Chien ST, Jiang WC, Yet SF, Wang J. The effect of heat treatment toward glycerol-based, photocurable polymeric scaffold: mechanical, degradation and biocompatibility. Polymers (Basel). 2021;13(12):1960. (IF=4.967; R/C=16/90, POLYMER SCIENCE)
- Jiang WC†, Chen CM†, Hamdin CD, Orekhov AN, Sobenin IA, Layne MD, Yet SF. Therapeutic Potential of heme oxygenase-1 in aneurysmal diseases. Antioxidants (Basel). 2020;9(11):1150. [†, equal contribution] (IF=7.675; R/C=4/63, CHEMISTRY, MEDICINAL)
- Chen CH, Ho YC, Ho HH, Liang LY, Jiang WC, Lee GL, Lee JK, Hsu YJ, Kuo CC, Wu KK, Yet SF. Tryptophan metabolite 5-methoxytryptophan ameliorates arterial denudation-induced intimal hyperplasia via opposing effects on vascular endothelial and smooth muscle cells. Aging (Albany NY). 2019;11(19):8604-8622. (IF=5.955; R/C=15/54, GERIATRICS & GERONTOLOGY)
- Lai YL†, Lin CY†, Jiang WC†, Ho YC, Chen CH, Yet SF. Loss of heme oxygenase-1 accelerates mesodermal gene expressions during embryoid body development from mouse embryonic stem cells. Redox Biol. 2018;15:51-61. [†, equal contribution] (IF=10.787; R/C=27/296, BIOCHEMISTRY & MOLECULAR BIOLOGY)
- Jiang WC, Cheng YH, Yen MH, Chang Y, Yang VW, Lee OK. Cryo-chemical decellularization of the whole liver for mesenchymal stem cells-based functional hepatic tissue engineering. Biomaterials. 2014;35(11):3607-3617. (IF=15.304; R/C=3/44, MATERIALS SCIENCE, BIOMATERIALS)