蔡佩君副教授::國立陽明交通大學解剖學及細胞生物學研究所

蔡佩君副教授

Pei-Jiun Tsai, Ph.D. Associate Professor

辦公室 A132 # 67987

實驗室 A129 # 65433,65434

pjtsai@vghtpe.gov.tw；pjtsai@nycu.edu.tw

實驗室介紹

歡迎來到我們的實驗室。

我們正在研究主題的是幹細胞在糖尿病動物模式上的治療效果。我們長遠的目標是藉由幹細胞或其衍生物來發展出新的治療方式，使得糖尿病患者有治癒的希望。

另外我們與陽明大學陳天華教授及張明超教授、國衛院司徒慧康副院長、國防醫學院徐佳福教授有密切合作，並與台北榮總張效煌醫師、周伯鑫醫師、賴峻毅醫師及壢新醫院蕭振源醫師等臨床醫師，組成龐大的研究團隊陣容，共同參與肝臟、胰臟、心臟、骨頭及幹細胞的相關研究。

實驗室研究方向

糖尿病是一種由於胰島素缺乏或是胰島素的阻抗所引起的疾病。而糖尿病所導致的高血糖症，會對患者造成一系列的急性或慢性的健康問題，但到目前為止，卻還沒有一種治療方式可以完全治癒糖尿病。而在許多文獻指出幹細胞具有高度增生及多分化潛能，並且能調解免疫反應。因此我們實驗室藉由這些幹細胞的特性，來達到治療糖尿病的效果。

我們實驗室將實驗分為兩階段，在細胞實驗方面，我們將來自臍帶的瓦頓氏凝膠間葉幹細胞分離純化，並將細胞在正常氧氣濃度或低氧氣濃度環境下培養，進行包括形態學、細胞生長及自我更新能力、多分化潛能測試，並測試細胞遷移能力、免疫抑制、抗細胞凋亡的功能。

在動物實驗方面，我們將NOD小鼠、大鼠、豬…等動物誘發成糖尿病動物模式，利用不同條件下培養的幹細胞或其分化細胞注射到動物體內，比較這些不同治療方式，對於糖尿病的治療效果及其機制的探討。

教師資訊

蔡佩君副教授

現職

國立陽明交通大學解剖學及細胞生物學研究所副教授
臺北榮民總醫院重症醫學部重症加護外科主治醫師

學歷

國立陽明大學臨床醫學研究所博士班
國立陽明大學醫學系

經歷

臺北榮民總醫院外科部總醫師
臺北榮民總醫院急診部急診外傷科總醫師
臺北榮民總醫院重症醫學部總醫師

重要獎項與榮譽

國立陽明大學107學年度醫學院院級教學傑出獎

研究專長

重症醫學、消化外科及幹細胞研究

研究概況

探討臍帶瓦頓氏間葉幹細胞對糖尿病動物模式的治療效果

發表論文

Chu KA, Yeh CC, Hsu CH, Hsu CW, Kuo FH, Tsai PJ, Fu YS.. Reversal of Pulmonary Fibrosis: Human Umbilical Mesenchymal Stem Cells from Wharton's Jelly versus Human-Adipose-Derived Mesenchymal Stem Cells. Int J Mol Sci. 2023; 24(8):6948 (SCI).
Chen CW, Chen LK, Huang TY, Yang DM, Liu SY, Tsai PJ, Chen TH, Lin HF, Juan CC.. Nitric Oxide Mobilizes Intracellular Zn2+ via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation. Int J Mol Sci. 2022; 23(10):5488 (SCI).
Kao SY, Chen TH, Wang CY, Hsiao CY, Chiang CS, Chou SC, Chen JY, Tsai PJ*.. Surgical Intervention Strategies of Necrotizing Pancreatitis With Abdominal Compartment Syndrome. Pancreas. 2021 Nov-Dec 01;50(10):1415-1421 2021; 50(10):1415-1421 (SCIE).
Chang HH, Chang CH, Hsiao CY, Kao SY, Chen JY, Chen TH, Tsai PJ.. Diabetes Is the Most Critical Risk Factor of Adverse Complications After Peritoneal Dialysis Catheter Placement. Front Med (Lausanne). 2021; 8:719345 (SCI).
Hsiao CY, Chen TH, Chu TH, Ting YN, Tsai PJ*, Shyu JF*.. Calcitonin Induces Bone Formation by Increasing Expression of Wnt10b in Osteoclasts in Ovariectomy-Induced Osteoporotic Rats. Front Endocrinol (Lausanne). 2020; 11:613 (SCI).
Chen TH, Kao SY, Chang HH, Shyu JF, Su CH, Tsai PJ*. Chronic Mesenteric Volvulus with Superior Mesenteric Venous Thrombosis: A Case Report. Clinics in Surgery 2020; (OI).
Chen TH, Kao SY, Chang HH, Shyu JF, Su CH, Tsai PJ* A Case Report of a Pancreatic Sarcoma Combined with Autoimmune Pancreatitis. Clinics in Surgery 2020; : (OI).
Chen TH, Su CH, Hsiao CY, Kao SY, Tsai PJ* Preemptive light sedation in intensive care unit may reduce pulmonary complications in geriatric receiving pancreaticoduodenectomy. Journal of the Chinese Medical Association 2020 (SCI).
Hsiao CY, Chen TH, Huang BS, Chen PH, Su CH, Shyu JF, Tsai PJ* Comparison between the therapeutic effects of differentiated and undifferentiated Wharton's jelly mesenchymal stem cells in rats with streptozotocin-induced diabetes. World Journal of Stem Cells 2020; 12(2): (SCI).
Tsai PJ, Yeh CC, Huang WJ, Min MY, Huang TH, Ko TL, Huang PY, Chen TH, Hsu Sanford PC *, Soong BW* and Fu YS*. Xenografting of human umbilical mesenchymal stem cells from Wharton's jelly ameliorates mouse spinocerebellar ataxia type 1. Translational Neurodegeneration 2019; 8(29): (SCI).
Chu KA, Wang SY, Yeh CC, Fu TW, Fu YY, Ko TL, Chiu MM, Chen TH, Tsai PJ*, Fu YS*. Reversal of bleomycin-induced rat pulmonary fibrosis by a xenograft of human umbilical mesenchymal stem cells from Wharton's jelly. Theranostics 2019; 9(22): (SCI).
Chen MS, Lin CY, Chiu YH, Chen CP, Tsai PJ, Wang HS. IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway. Stem Cells International 2018(SCI).
Hsiao CY, Tsai JP, Chu PC, Liu SI, Pan CH, Chen CP, Su CH, Weng ZC, Chen TH, Shyu JF*, Chang HH*, and Wang HS*. Transplantation of Wharton's jelly mesenchymal stem cells to improve cardiac function in myocardial infarction rats. Journal of Biomedical Sciences 2016; 5(1): (OI).
Kao SY, Shyu JF, Wang HS, Hsiao CY, Su CH, Chen TH, Weng ZC, Tsai PJ*. Transplantation of Hepatocyte-like Cells Derived from Umbilical Cord Stromal Mesenchymal Stem Cells to Treat Acute Liver Failure Rat. Journal of Biomedical Sciences 2016; 4(1): (OI).
Cheng CL, Chang HH, Chen TH, Tsai PJ, Huang YT, Huang PJ, Lin SY. Spectral and morphological classification of different chronic and acute Taiwanese gallstones via FTIR, SEM and ESEM-EDX microanalyses. DIGESTIVE AND LIVER DISEASE 2016; 48(5):519-27 (SCI).
Lin CY, Zu CH, Yang CC, Tsai PJ, Shyu JF, Chen CP, Weng ZC, Chen TH, Wang HS. IL-1β-induced mesenchymal stem cell migration involves MLCK activation via PKC signaling. CELL TRANSPLANTATION 2015; 24(10):2011-28 (SCI).
Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF. Undifferentiated Wharton's Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T Cell-Mediated Autoimmunity in Non-Obese Diabetic Mice. CELL TRANSPLANTATION 2015; 24(8):1555-70 (SCI).
Cheng CL, Chang HH, Chen TH, Tsai PJ, Ko SC, Chu YT, Huang PJ, Lin SY. Diagnosis and clinical characteristics of acute gallbladder sludge in a patient with acute myocarditis and acute cholecystitis, as compared with common chronic gallstones. Biomedical Spectroscopy and Imaging 2015; 4(1):67-9 (OI).
Kao SY, Shyu JF, Wang HS, Lin CH, Su CH, Chen TH, Weng ZC, Tsai PJ. Comparisons of Differentiation Potential in Human Mesenchymal Stem Cells from Wharton's Jelly, Bone Marrow, and Pancreatic Tissues. Stem Cells International 2015; (SCI).
Chang YC, Lee KH, Chen TH, Tsai PJ, Chen PY, Guo MC, Lin SA, Chen JY, Yang WC, Ng YY.. A case of intraperitoneal fracture of a double-cuff Tenckhoff catheter. PERITONEAL DIALYSIS INTERNATIONAL 2014; 34(1):132-4 (SCI).
Kao SY, Lee TC, Weng ZC, Chen TH, Tsai PJ*. Treatment of obturator hernia in a patient undergoing peritoneal dialysis. PERITONEAL DIALYSIS INTERNATIONAL 2014; 34(7):803-5 (SCI).
Tsai PJ, Wang HS, Lin CH, Weng ZC, Chen TH, Shyu JF. Intraportal injection of insulin-producing cells generated from human bone marrow mesenchymal stem cells decreases blood glucose level in diabetic rats. ENDOCRINE RESEARCH 2014; 39(1):26-33 (SCI).
Tsai PJ, Wang SE, Shyr YM, Chen TH, Su CH, Wu CW. Diagnostic and therapeutic dilemmas in periampullary lesions. HEPATO-GASTROENTEROLOGY 2012; 117:1621-5 (SCI).
Tsai PJ, Wang HS, Shyr YM, Weng ZC, Tai LC, Shyu JF, Chen TH. Transplantation of insulin-producing cells from umbilical cord mesenchymal stem cells for the treatment of streptozotocin-induced diabetic rats. JOURNAL OF BIOMEDICAL SCIENCE 2012; 19(1):47 (SCI).
Tsai PJ, Liu KY, Wang SE, Shyr YM, Su CH, Chen TH. Solitary neurofibroma of the pancreas body not associated with type 1 neurofibromatosis. Journal of the Chinese Medical Association: JCMA 2012; 75(3):132-5 (SCI).
.Chien JS, Tsai PJ, Liu KY, Wang SE, Shyr YM, Su CH, Chen TH. Open Suture Repair and Open Onlay Technique for Incisional Hernia in Elderly Patients with Multiple Comorbidities. International Journal of Applied Science and Technology 2011; 1(3):34-40 (OI).
Liu KY, Tsai PJ, King KL, Chen TH, Shyr YM, Su CH. Pseudoaneurysm of the iliac artery secondary to Aspergillus infection after kidney transplantation. Journal of the Chinese Medical Association: JCMA 2009; 72(12):654-6. (SCI).

受邀演講

The therapeutic effect and mechanism of human umbilical cord Wharton's Jelly mesenchymal stem cells on bleomycin-induced pulmonary fibrosis rat,2020年 ISOMRM台灣國際再生醫學材料應用研討會,2020/12/13.
異種移植人類臍帶瓦頓式凝膠間質幹細胞逆轉Bleomycin誘導的大鼠肺纖維化,中國解剖學會/第二屆海峽兩岸暨港澳解剖學青年科學家論壇,2020/10/17.
以胃體分隔手術治療巨大消化性潰瘍穿孔的動物實驗與臨床應用,2018年中國—東盟衰老與疾病學術論壇暨廣西解剖學會2018年學術年會.
糖尿病的再生治療應用,2018年中國解剖學會學術年會.
擊退糖尿病的新希望-幹細胞治療,2017年BioPhalanx 生技研發論壇演講.
臍帶間質幹細胞的糖尿病治療機轉,2019年中國解剖學會學術年會.