鄭瓊娟教授(兼所長科主任)

現職

• 陽明交通大學解剖學及細胞生物學科暨研究所教授

學歷

• 加州大學洛杉磯分校解剖學及細胞生物學研究所博士
• 臺灣大學醫學院解剖學研究所碩士
• 臺灣大學醫學院物理治療學系學士

經歷

• 輔仁大學醫學系助理教授
• 台醫生物科技公司研究員
• 美國加州理工學院博士後研究員
• 美國加州大學洛杉磯分校博士後研究員
• 臺灣大學醫學院解剖學研究所助教

重要獎項與榮譽

• 陽明大學106學年度校級教學優良獎
• 陽明大學100學年度醫學院教學優良琉璃獎座
• 陽明大學97學年度校級教學優良獎

研究專長

• 離子通道、細胞生物學、神經科學

發表論文

1. C.-H. Hsieh, C.-C. Chou, Y.-C. Fang, P.-H. Hsu, Y.-H. Chiu, C.-S. Yang, G.-M. Jow, C.-Y. Tang, and C.-J. Jeng* (2023) 14-3-3 proteins regulate cullin 7-mediated Eag1 degradation. Cell & Bioscience 13:18. doi: 10.1186/s13578-023-00969-w.
2. L.-H. Changa, N.-F. Chib, C.-Y. Chen, Y.-S. Linb, S.-L. Hsub, J.-Y. Tsai, H.-C. Huang, C.-J. Linb, C.-P. Chung, C.-Y. Tung, C.-J. Jeng, Y.-C. Lee, Y.-T. Liu, I.-H. Lee* (2022) Monogenic causes in familial stroke across intracerebral hemorrhage and ischemic stroke subtypes identified by whole exome sequencing. Cellular and Molecular Neurobiology, doi: 10.1007/s10571-022-01315-3.
3. Y.-L. Gan, C.-Y. Wang, R.-H. He, P.- C. Hsu, H.- H. Yeh, T.- H. Hsieh, H.- C. Lin, M.- Y. Cheng , C.-J. Jeng, M.-C. Huang* and Y.-H. Lee* (2022) FKBP51 mediates resilience to infammation-induced anxiety through regulation of glutamic acid decarboxylase 65 expression in mouse hippocampus. Journal of Neuroinflammation 19:152. doi:10.1186/s12974-022-02517-8.
4. Y.-C. Fang, S.-J. Fu, P.-H. Hsu, P.-T. Chang, J.-J. Huang, Y.-C. Chiu, Y.-F. Liao, G.-M. Jow, C.-Y. Tang*, and C.-J. Jeng* (2021) Identification of MKRN1 as a second E3 ligase for Eag1 potassium channels reveals regulation via differential degradation. Journal of Biological Chemistry 296, 100484.
5. C.-T. Hsiao, T.F. Tropea., S.-J. Fu, T.M. Bardakjian, P. Gonzalez-Alegre, B.-W. Soong, C.-Y. Tang*, C.-J. Jeng* (2021) Rare gain-of-function KCND3 variant associated with cerebellar ataxia, parkinsonism, cognitive dysfunction, and brain iron accumulation. International Journal of Molecular Sciences. 22, 8247. doi: 10.3390/ijms22158247.
6. G. Zanni*, C.-T. Hsiao, S.-J. Fu, C.-Y. Tang, A. Capuano, L. Bosco, F. Graziola, E. Bellacchio, S.. Servidei., G. Primiano., B.-W. Soong and C.-J. Jeng* (2021) Novel KCND3 variant underlying nonprogressive congenital ataxia or SCA19/22 disrupt Kv4.3 protein expression and K+ currents with variable effects on channel properties. International Journal of Molecular Sciences. 22, 4986. doi: 10.3390/ijms22094986.
7. C.-S. Chiang., S.-J. Fu., C.-L. Hsu, C.-J. Jeng, C.-Y. Tang, Y.-S. Huan, S.-C. Tang* (2021) Neuronal exosomes secreted under oxygen-glucose deprivation/reperfusion presenting differentially expressed miRNAs and affecting neuronal survival and neurite outgrowth. NeuroMolecular Medicine. doi: 10.1007/s12017-020-08641-z.
8. S.-J. Fu., M.-C. Hu, C.-T. Hsiao, A.-T. Cheng, T.-Y. Chen, C.-J. Jeng*, and C.-Y. Tang* (2021) Regulation of ClC-2 chloride channel proteostasis by molecular chaperones: correction of leukodystrophy-associated defect. International Journal of Molecular Sciences. 22, 5859. doi: 10.3390/ijms22115859.
9. S.-J. Fu, M.-C. Hu, Y.-J. Peng, H.-Y. Fang, C.-T. Hsiao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2020) CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. Cells 9, 1332; doi:10.3390/cells9061332
10. C.-J. Jeng, S.-J. Fu, C.-Y. You, Y.-J. Peng, C.-T. Hsiao, T.-Y. Chen, C.-Y. Tang* (2020) Defective gating and proteostasis of human CLC-1 chloride channel: molecular pathophysiology of myotonia congenital. Frontiers in Neurology Vol 11, Article 76; Doi: 10.3389/fneur.2020.00076
11. C.-T. Hsiao, S.-J. Fu, Y.-T. Liu, Y.-H. Lu, C.-Y. Zhong, C.-Y. Tang, B.-W. Soong*, C.-J. Jeng* (2019) Novel SCA19/22-associated KCND3 mutations disrupt human KV4.3 protein biosynthesis and channel gating. Human Mutation 40:2088–2107. doi: 10.1002/humu.23865
12. Y.-J. Peng, Y.-C. Lee, S.-J. Fu, Y.-C. Chien, Y.-F. Liao, T.-Y. Chen, C.-J. Jeng*, C.-Y. Tang* (2018) FKBP8 enhances protein stability of CLC-1 chloride channel at the plasma membrane. International Journal of Molecular Sciences. 9: 3783, doi:10.3390/ijms19123783
13. P.-H. Hsu, Y.-T. Ma, Y.-C. Fang, J.-J. Huang, Y.-L. Gan, P.-T. Chang, G.-M. Jow, C.-Y. Tang*, C.-J. Jeng* (2017) Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels. Scientific Reports 7:40825, DOI: 10.1038.
14. S.-J. Fu, C.-J. Jeng, C.-H. Ma, Y.-J. Peng, C.-M. Lee, Y.-C. Fang, Y.-C. Lee, S.-C. Tang, M.-C. Hu, C.-Y. Tang* (2017) Ubiquitin ligase RNF138 promotes episodic ataxia type 2-associated aberrant degradation of human CaV2.1 (P/Q-type) calcium channels.  Journal of Neuroscience 37(9):2485–2503.
15. P.-H. Hsu, Y.-C. Chiu, T.-F. Lin, C.-J. Jeng* (2016) Ca2+-binding protein centrin 4 is a novel binding partner of rat Eag1 K+ channels. FEBS Open Bio doi:10.1002/2211-5463.12045.
16. Y.-C. Teng, C.-J. Jeng, H.-J. Huang, A. M.-Y. Lin (2015) Role of autophagy in arsenite-induced neurotoxicity: The involvement of alpha-synuclein. Toxicology Letters 233: 239-245.
17. T.-F. Lin, G.-M Jow, H.-Y. Fang, S.-J. Fu, H.-H. Wu, M.-M. Chiu, C.-J. Jeng* (2014) The eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels. PLoS ONE 9(10): e110423.
18. T.-F. Lin, I-W. Lin, S.-C. Chen, H.-H. Wu, C.-S. Yang, H.-Y Fang, M.-M. Chiu, C.-J. Jeng* (2014) The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains. Journal of Biological Chemistry 289(33):22815-22834.
19. C.-C. Chuang, G.-M. Jow, H.-M. Lin, Y.-H. Weng, J.-H. Hu, Y.-J. Peng, Y.-C. Chiu, M.-M. Chiu, C.-J. Jeng* (2014) The punctate localization of rat Eag1 K+ channels. BMC Neuroscience 15:23.
20. C.-K. Liao, C.-J. Jeng, H.-S. Wang, S.-H. Wang, J.C. Wu (2013) Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway.  PLoS ONE 8(11): e79350.
21. P.-H. Hsu, S.-C. Miawa, C.-C. Chuang, P.-Y. Chang, S.-J. Fu, G.-M. Jow, M.-M. Chiu, C.-J. Jeng* (2012) 14-3-3theta is a Binding Partner of Rat Eag1 potassium Channels. PLoS ONE 7(7): e41203.
22. S.-H. Yang, C.-C. Liao, Y. Chen, J.-P. Syu, C.-J. Jeng*, S.-M. Wang (2012) Daidzein induces neuritogenesis in DRG neuronal cultures. Journal of Biomedical Science 19:80.
23. I.-H. Chen, J.-H. Hu, G.-M. Jow, C.-C. Chuang, T.-T. Lee, D.-C. Liu, C.-J. Jeng* (2011) The distal end of carboxyl-terminus is not essential for the assembly of rat Eag1 potassium channels.  Journal of Biological Chemistry 286(31) 27183–27196.
24. S.-H. Yang; C.-J. Jeng, C-H Chen, Y. Chen, Y.-C. Chen, and S.-M. Wang* (2011) Schisandrin enhances dendrite outgrowth and synaptogenesis in primary cultured hippocampal neurons.  Journal of the Science of Food and Agriculture 91(4): 694–702.

受邀演講

1. Proteostatic mechanism  of neuronal K+  channels: Pathophysiological implications in neurological diseases, 國衛院細胞及系統醫學研究所, 7/14/2022.
2. Molecular basis and pathological significance of K+ channel degradation, 成功大學醫學院細胞生物與解剖學研究所, 10/27/2021.
3. Protein biosynthesis mechanisms of neuronal K+ channel degradation, 成功大學醫學院細胞生物與解剖學研究所, 5/1/2019.
4. Proteostatic mechanism of Eag1 potassium channel, 29th Ion Channel Meeting, CANAUX IONIQUES, Sète, France, 9/10/2018.
5. Regulation of ether-à-go-go potassium channel expression by RING E3 ubiquitin ligases and 14-3-3 proteins, 政治大學神經科學研究所, 5/22/2018.
6. Regulation of ether-à-go-go potassium channel expression by ring E3 ubiquitin ligases, The 33th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/24/2018.
7. Protein interaction mechanisms of Eag potassium channels, Internal Symposium in Osaka University, Osaka, Japan, 8/3/2017.
8. Protein targeting and molecular assembly of ether-à-go-go potassium channels, The 31th Joint Annual Conference of Biomedical Science, Taipei, Taiwan, 3/26/2016.
9. Protein interaction mechanisms of ether-à-go-go potassium channels, 國防大學醫學院生物及解剖學研究所, 12/8/2016.
10. Molecular assembly of ether-à-go-go potassium channels, 陽明大學生理學研究所, 3/19/2015.
11. Molecular assembly and protein association of ether-à-go-go potassium channels, 高雄榮民總醫院 教研部, 10/31/2014.
12. Molecular assembly and protein association of Eag K+ channels, 生科院-週三中午有約, 6/5/2013.
13. Structural and functional characterization of ether-à-go-go potassium channel, 輔仁大學醫學院基礎醫學研究所, 11/29/2012.
14. Molecular assembly and protein association of neuronal potassium channels, The 26th Joint Annual Conference of Biomedical Sciences, 3/20/2011.